Associations between anthropometric indicators and refraction in school-age children during the post-COVID-19 era

PurposeTo explore the associations between anthropometric indicators and refraction in school-aged children in the post-COVID-19 era.MethodsData were collected from 25,644 children aged 7 to 12 years in 48 elementary schools in Tianjin. The comprehensive examination included height, weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), refraction, and calculation of BMI, with a follow-up visit after 6 months. Myopia was defined as spherical equivalent refraction (SER) ≤-0.50 diopter (D). Bivariate correlation coefficients and multiple linear regression models were used to explore the cross-sectional and longitudinal associations between anthropometric indicators (height, weight, BMI, SBP, and DBP) and refraction.ResultsThe mean changes in height, weight, BMI, SBP, DBP, and SER of the participants were 4.03 ± 2.18 cm, 3.10 ± 2.39 kg, 0.45 ± 1.16 kg/m2, 2.26 ± 14.74 mmHg, 2.18 ± 11.79 mmHg and −0.17 ± 0.51 D, respectively. Overall, height, weight, BMI, SBP, and DBP were all correlated with SER (r = −0.324, r = −0.234, r = −0.121, r = −0.112, r = −0.066, both p < 0.001), and changes in height and weight were correlated with changes in SER (r = −0.034, −0.031, both p < 0.001). Furthermore, multiple linear regression analysis revealed that the association of BMI, SBP, and DBP with SER was significant in myopic children but not in non-myopic children. The association between changes in weight and changes in SER was only present in non-myopic children but not in myopic children.ConclusionHeight and weight were negatively correlated with SER in both cross-sectional analysis and longitudinal changes, indicating that children's height, weight and growth rate may be used as a reference indicator for myopia risk prediction and myopia progression monitoring

Investigation on Structural Mapping Laws of Sensitive Geometric Errors Oriented to Remanufacturing of Three-Axis Milling Machine Tools

Three-axis milling machine tools are widely used in manufacturing enterprises, and they have enormous potential demands for remanufacturing to improve their performance. During remanufacturing a three-axis milling machine tool, the structure needs to be reconstructed, so it is necessary to identify sensitive geometric errors of the remanufactured machine tool. In the traditional sensitive geometric error identification method, complex error modeling and analysis must be conducted. Therefore, professional knowledge is required, and the process of the identification is cumbersome. This paper focused on the quick identification of sensitive geometric errors for remanufacturing of three-axis milling machine tools. Firstly, sensitive geometric errors of a three-axis milling machine tool were identified based on the multi-body system theory and partial differential method. Then, mapping laws between the sensitive geometric errors and the machine tool structure were firstly presented. According to the proposed mapping laws, the sensitive geometric errors can be identified quickly and easily without complex error modeling and analysis. Finally, the simulation and experiment show that the straightness error of milling is improved up to 0.007 mm by compensating the sensitive geometric errors identified by the proposed mapping laws. The table lookup method based on the mapping laws can quickly identify the sensitive geometric errors of three-axis milling machine tools, which is beneficial for the efficiency and precision of remanufacturing of machine tools

Effect of Assembly Errors on Ground Tooth Surface Deviations for Large-Scale CNC Gear Profile Grinding Machines

Assembling plays a significant role in the performance of large-scale CNC gear profile grinding machines. An approach in the deviation evaluation of ground tooth surfaces taking into account assembly errors is proposed in this paper. Based on the error transmission chain of the profile grinding system and the conjugate motion relationship between the grinding wheel and the workpiece, the ground tooth surface model including assembly errors was established using the surface envelope method. Then, the effect of assembly errors on deviations of the profile grinding tooth surface was quantitatively analyzed. The optimized distribution of assembly errors and machining verifications were performed on large-scale CNC gear profile grinding machines. The results show that the proposed method is effective at ensuring ground tooth surface deviations for large-scale CNC gear profile grinding machines

Research on High Performance Milling of Engineering Ceramics from the Perspective of Cutting Variables Setting

The setting of cutting variables for precision milling of ceramics is important to both the machined surface quality and material removal rate (MRR). This work specifically aims at the performance of corner radius PCD (polycrystalline diamond) end mill in precision milling of zirconia ceramics with relatively big cutting parameters. The characteristics of the cutting zone in precision milling ceramics with corner radius end mill are analyzed. The relationships between the maximum uncut chip thickness (hmax) and the milling parameters including feed per tooth (fz), axial depth of cut (ap) and tool corner radius (rε) are discussed. Precision milling experiments with exploratory milling parameters that cause uncut chip thickness larger than the critical value were carried out. The material removal mechanism was also analyzed. According to the results, it is advisable to increase fz appropriately during precision milling ZrO2 ceramics with corner radius end mill. There is still a chance to obtain ductile processed surface, as long as the brittle failure area is controlled within a certain range. The appropriate increasing of ap, not only can prevent the brittle damage from affecting the machined surface, but also could increase the MRR. The milling force increases with increasing MRR, but the surface roughness can still be stabilized within a certain range

A Fluorine-Containing Main-Chain Benzoxazine/Epoxy Co-Curing System with Low Dielectric Constants and High Thermal Stability

A fluorine-containing main-chain benzoxazine (BAF-M-TB) was co-cured with biphenyl epoxy for the integrated circuit industry. The benzoxazine precursor was synthesized using 4,4′-(Hexafluoroisopropylidene)diphenol (bisphenol AF), 2,2′-Dimethyl-[1,1′-biphenyl]-4,4′-Diamine(M-TB), and paraformaldehyde. In addition, the 3,3′-(Oxybis(4,1-phenylene))bis(3,4-dihydro-2H-benzo[e][1,3]oxazine) (Benoxazine ODA-BOZ), which is a commercialized benzoxazine, was co-cured with biphenyl epoxy as a control. The two co-curing systems were referred to as EP/BAF-M-TB and EP/ODA-BOZ. The curing kinetics, rheological behavior, and thermal stability of the two co-curing systems were studied. Poly-EP/BAF-M-TB and poly-EP/ODA-BOZ quartz fiber cloth reinforced composites (QFRPs) were prepared using the prepreg laminating method in order to determine their mechanical, thermal, and dielectric properties. Both of them showed good thermal properties and dielectric properties. The dielectric constant of poly-EP/BAF-M-TB QFRP is in the range of 3.25–3.54 at the low frequency of 10 kHz–10 MHz. At the high frequency of 5 GHz, its dielectric constant is 3.16, which is better than that of poly-EP/ODA-BOZ QFRP. Additionally, the Td5 of poly-EP/BAF-M-TB was 398 °C in a nitrogen atmosphere, which is higher than that of poly-EP/ODA-BOZ

Effects of different proteases enzymatic extraction on the lipid yield and quality of Antarctic krill oil

This study was investigated the effects of six proteases (papain, compound proteinase, acidic protease, neutrase, pancreatin, and alcalase) on the lipid yield and quality of krill oil. The result shown that the krill oil extracted by alcalase and compound proteinase led to comparatively higher lipid yields (5.29% and 4.90%, respectively), Content of tocopherols and vitamin A, the content of omega‐3 polyunsaturated fatty acids (PUFAs) and phospholipids extracted by alcalase was relatively higher. Control and alcalase had comparatively higher concentration of astaxanthin. On the whole, compared with the extraction of solvent, enzymatic hydrolysis could improve the quality and the lipid yield of krill oil. Therefore, enzymatic hydrolysis could be used as a better method to extract krill oil

Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers

Abstract Background Mitiglinide is a widely used agent for diabetic treatment. We established a pharmacokinetic-pharmacodynamic (PK-PD) model to illustrate the relationship between mitiglinide plasma concentration and its glucose lowering effects in healthy volunteers. Methods The volunteers participated in the test after the administration of a single dose of 10 mg mitiglinide. The drug concentration in Plasma and the values of glucose levels were determined by LC-MS/MS assay and hexokinase method. A PK-PD model was established with a series of equations to describe the relationship between plasma medicine and glucose, and the equations were solved numerically and fitted to the data with the Phoenix NLME software. Results The results of the two-compartment model analysis were based on the maximum likelihood criterion and visual inspection of the fittings. The terminal elimination half-life (t 1/2) was 1.69 ± 0.16 h and the CL/F was 7.80 ± 1.84 L/h. The plasma glucose levels began to decline by 0.2 h, and hit its bottom decreasing values of 2.6 mg/L at 0.5 h after administration. The calculated parameter and fitting curve indicated that the model established in our experiment fitted well. Conclusions A PK/PD model illustrates that the relationship between mitiglinide concentration in plasma and glucose lowering effect in healthy volunteers was established. The results of our experiment suggested that the model can be used reasonably to predict the relationship between PK and PD in mitiglinide, which could be used in diabetes mellitus dosage control in clinical trials and other fields

NAD+ Modulates the Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells via Akt Signaling Pathway

Nicotinamide adenine dinucleotide hydrate (NAD+) acts as the essential component of the tricarboxylic citric acid (TCA) cycle and has important functions in diverse biological processes. However, the roles of NAD+ in regulating adult neural stem/progenitor cells (aNSPCs) remain largely unknown. Here, we show that NAD+ exposure leads to the reduced proliferation and neuronal differentiation of aNSPCs and induces the apoptosis of aNSPCs. In addition, NAD+ exposure inhibits the morphological development of neurons. Mechanistically, RNA sequencing revealed that the transcriptome of aNSPCs is altered by NAD+ exposure. NAD+ exposure significantly decreases the expression of multiple genes related to ATP metabolism and the PI3k-Akt signaling pathway. Collectively, our findings provide some insights into the roles and mechanisms in which NAD+ regulates aNSPCs and neuronal development